منابع مشابه
Human Epigenome Project—Up and Running
PLoS Biology | http://biology.plosjournals.org Epigenomics is one of the many ‘omics’ that is being talked about in the wake of the Human Genome Project. But what is an epigenome, and why have the Wellcome Trust Sanger Institute (Hinxton, United Kingdom) and Epigenomics AG (Berlin, Germany) recently announced the launch of the Human Epigenome Project (HEP), a five-year undertaking during which ...
متن کاملA blueprint for a Human Epigenome Project: the AACR Human Epigenome Workshop.
Epigenetic processes control the packaging and function of the human genome and contribute to normal and pathologic states, including cancer. The time is ripe to undertake an international effort to identify all the chemical changes and relationships between chromatin constituents that provide function to the genetic code. A timely workshop of leading experts, convened by the American Associati...
متن کاملPerspectives of International Human Epigenome Consortium
As the International Human Epigenome Consortium (IHEC) launched officially at the 2010 Washington meeting, a giant step toward the conquest of unexplored regions of the human genome has begun. IHEC aims at the production of 1,000 reference epigenomes to the international scientific community for next 7-10 years. Seven member institutions, including South Korea, Korea National Institute of Healt...
متن کاملSequence-Level Mechanisms of Human Epigenome Evolution
DNA methylation and chromatin states play key roles in development and disease. However, the extent of recent evolutionary divergence in the human epigenome and the influential factors that have shaped it are poorly understood. To determine the links between genome sequence and human epigenome evolution, we examined the divergence of DNA methylation and chromatin states following segmental dupl...
متن کاملMomentum building for human epigenome project.
Epigenetics does not get the recognition it deserves, say its proponents. " Our struggle in this fi eld has been to convince the community that epigenetics really has a major role in human disease , " said Peter Jones , D.Sc., director of the Norris Comprehensive Cancer Center at the University of Southern California in Los Angeles. Jones and 39 other scientists are now trying to convince fundi...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2003
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0000082